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Ras and Signal Transducer and Activator of Transcription (STAT) Are Essential and Sufficient Downstream Components of Janus Kinases in Cell Proliferation
Cytokines exert their activities in cell growth and differentiation by binding specific cell membrane receptors. Janus kinases (JAKs) are cytoplasmic protein tyrosine kinases that physically interact with intracellular domains of the cytokine receptors and they play crucial roles in transducing sign...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2000
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926385/ https://www.ncbi.nlm.nih.gov/pubmed/10835498 http://dx.doi.org/10.1111/j.1349-7006.2000.tb00977.x |