Characterization of the Interaction of TZT‐1027, a Potent Antitumor Agent, with Tubulin

TZT‐1027, a derivative of dolastatin 10 isolated from the Indian Ocean sea hare Dolabella auricularia in 1987 by Pettit et al., is a potent antimicrotubule agent. We have compared the activity of TZT‐1027 with that of dolastatin 10 as well as the vinca alkaloids vinblastine (VLB), vincristine (VCR)...

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Detalles Bibliográficos
Autores principales: Natsume, Tsugitaka, Watanabe, Jun‐ichi, Tamaoki, Satoru, Fujio, Nami, Miyasaka, Katsuhiko, Kobayashi, Motohiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2000
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926414/
https://www.ncbi.nlm.nih.gov/pubmed/10920282
http://dx.doi.org/10.1111/j.1349-7006.2000.tb01007.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926414/
https://www.ncbi.nlm.nih.gov/pubmed/10920282
http://dx.doi.org/10.1111/j.1349-7006.2000.tb01007.x

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