A Novel Class of Antitumor Prodrug, 1‐(2′‐Oxopropyl)‐5‐fluorouracil (OFU001), That Releases 5‐Fluorouracil upon Hypoxic Irradiation

We have been developing prodrugs of anticancer agents such as 5‐fluorouracil (5‐FU) that are activated by irradiation under hypoxic conditions via one‐electron reduction. Among them, OFU001 [1‐(2′‐oxopropyl)‐5‐fluorouracil] is a prototype radiation‐activated prodrug. In this study, we investigated t...

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Detalles Bibliográficos
Autores principales: Shibamoto, Yuta, Zhou, Ling, Hatta, Hiroshi, Mori, Mayuko, Nishimoto, Sei‐ichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2000
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926472/
https://www.ncbi.nlm.nih.gov/pubmed/10804292
http://dx.doi.org/10.1111/j.1349-7006.2000.tb00963.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926472/
https://www.ncbi.nlm.nih.gov/pubmed/10804292
http://dx.doi.org/10.1111/j.1349-7006.2000.tb00963.x

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