Cargando…

A Novel Class of Antitumor Prodrug, 1‐(2′‐Oxopropyl)‐5‐fluorouracil (OFU001), That Releases 5‐Fluorouracil upon Hypoxic Irradiation

We have been developing prodrugs of anticancer agents such as 5‐fluorouracil (5‐FU) that are activated by irradiation under hypoxic conditions via one‐electron reduction. Among them, OFU001 [1‐(2′‐oxopropyl)‐5‐fluorouracil] is a prototype radiation‐activated prodrug. In this study, we investigated t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shibamoto, Yuta, Zhou, Ling, Hatta, Hiroshi, Mori, Mayuko, Nishimoto, Sei‐ichi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2000
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926472/ https://www.ncbi.nlm.nih.gov/pubmed/10804292 http://dx.doi.org/10.1111/j.1349-7006.2000.tb00963.x

Ejemplares similares

Radiation- and Photo-induced Activation of 5-Fluorouracil Prodrugs as a Strategy for the Selective Treatment of Solid Tumors
por: Ito, Takeo, et al.
Publicado: (2008)

Pharmacokinetic Modulation of Plasma 5‐Fluorouracil Concentrations to Potentiate the Antitumor Activity of Continuous Venous Infusion of 5‐Fluorouracil
por: Fujii, Setsuro, et al.
Publicado: (1989)

Synergistic Antitumor Effect of Dichloroacetate in Combination with 5-Fluorouracil in Colorectal Cancer
por: Tong, Jingtao, et al.
Publicado: (2011)

Pharmacokinetic properties and antitumor efficacy of the 5-fluorouracil loaded PEG-hydrogel
por: Yi, Hee, et al.
Publicado: (2010)

The effect of microneedles on the skin permeability and antitumor activity of topical 5-fluorouracil
por: Naguib, Youssef W., et al.
Publicado: (2014)

Synergistic antitumor effect of puerarin combined with 5-fluorouracil on gastric carcinoma
por: GUO, XU-FENG, et al.
Publicado: (2015)

Synergic effect between 5-fluorouracil and celecoxib on hypoxic gastric cancer cells
por: Zhang, Xiao-Qian, et al.
Publicado: (2021)

Effects of the Plasma Concentration of 5‐Fluorouracil and the Duration of Continuous Venous Infusion of 5‐Fluorouracil with an Inhibitor of 5‐Fluorouracil Degradation on Yoshida Sarcomas in Rats
por: Fujii, Setsuro, et al.
Publicado: (1989)

GR-891: a novel 5-fluorouracil acyclonucleoside prodrug for differentiation therapy in rhabdomyosarcoma cells
por: Marchal, J A, et al.
Publicado: (1999)

Hyperammonemia Secondary to 5-Fluorouracil
por: Scott, Ashley, et al.
Publicado: (2023)

Schedule-dependent antitumor effects of 5-fluorouracil combined with sorafenib in hepatocellular carcinoma
por: Deng, Lifen, et al.
Publicado: (2013)

Antitumor Activity of BOF‐A2, a New 5‐Fluorouracil Derivative
por: Fujii, Setsuro, et al.
Publicado: (1989)

Synthesis and Antitumor Activity of Amino Acid Ester Derivatives Containing 5-Fluorouracil
por: Xiong, Jing, et al.
Publicado: (2009)

In vitro additive antitumor effects of dimethoxycurcumin and 5‐fluorouracil in colon cancer cells
por: Zhao, Huiying, et al.
Publicado: (2017)

Pyrotinib Sensitizes 5-Fluorouracil-Resistant HER2(+) Breast Cancer Cells to 5-Fluorouracil
por: Yi, Jianing, et al.
Publicado: (2020)

A novel oral prodrug-targeting transporter MCT 1: 5-fluorouracil-dicarboxylate monoester conjugates
por: Sun, Yixin, et al.
Publicado: (2019)

Mutual Prodrugs of 5‐Fluorouracil: From a Classic Chemotherapeutic Agent to Novel Potential Anticancer Drugs
por: Ciaffaglione, Valeria, et al.
Publicado: (2021)

Molecular Insights on the Cyclic Peptide Nanotube-Mediated Transportation of Antitumor Drug 5-Fluorouracil
por: Liu, Huifang, et al.
Publicado: (2010)

Synthesis, in vitro aerobic and hypoxic cytotoxicity and radiosensitizing activity of novel metronidazole tethered 5-fluorouracil
por: Abdi, Khosrou, et al.
Publicado: (2013)

Bioavailability and feasibility of subcutaneous 5-fluorouracil.
por: Borner, M. M., et al.
Publicado: (1993)

5-fluorouracil and cardiotoxicity: a review
por: Sara, Jaskanwal D., et al.
Publicado: (2018)

5-Fluorouracil-induced vasospastic angina
por: Ayyildiz, Orhan, et al.
Publicado: (2005)

5-Fluorouracil Rechallenge After Cardiotoxicity
por: Desai, Aakash, et al.
Publicado: (2020)

Fluorouracil (5-FU)-induced Cardiomyopathy
por: Thalambedu, Nishanth, et al.
Publicado: (2019)

Cardiotoxicities of 5-Fluorouracil and Other Fluoropyrimidines
por: Shiga, Taro, et al.
Publicado: (2020)

5-Fluorouracil–Induced Coronary Vasospasm
por: Arya, Sumedha, et al.
Publicado: (2018)

Efficacy of 5-Fluorouracil in the Treatment of Pterygium
por: Shah, Sobia U, et al.
Publicado: (2021)

5-Fluorouracil Cardiotoxicity: Known But Unknown
por: Brell, Joanna M.
Publicado: (2021)

Oxaliplatin and protracted venous infusion of 5-fluorouracil in patients with advanced or relapsed 5-fluorouracil pretreated colorectal cancer
por: Chau, I, et al.
Publicado: (2001)

A Comparative Study of the Efficacy of Intralesional 5 Fluorouracil vs Combination of 5 Fluorouracil with Triamcinolone Acetonide in Keloids
por: Monteiro, Rochelle C, et al.
Publicado: (2022)

Efficacy of Topical 5% 5-Fluorouracil with Needling versus 5% 5-Fluorouracil Alone in Stable Vitiligo: A Randomized Controlled Study
por: Zahra, Fatima T., et al.
Publicado: (2020)

Porokeratoma treated with topical 5% 5-fluorouracil cream
por: Li, Steve S., et al.
Publicado: (2021)

Enhanced therapeutic efficacy of 5'deoxy-5-fluorouridine in 5-fluorouracil resistant head and neck tumours in relation to 5-fluorouracil metabolising enzymes.
por: Peters, G. J., et al.
Publicado: (1989)

Antitumor effects and the underlying mechanism of licochalcone A combined with 5-fluorouracil in gastric cancer cells
por: Lin, Xiaolin, et al.
Publicado: (2017)

The Synergistic Antitumor Effect of 5-Fluorouracil Combined with Allicin against Lung and Colorectal Carcinoma Cells
por: Țigu, Adrian Bogdan, et al.
Publicado: (2020)

Simultaneous, But Not Consecutive, Combination With Folinate Salts Potentiates 5-Fluorouracil Antitumor Activity In Vitro and In Vivo
por: Di Paolo, Antonello, et al.
Publicado: (2017)

Mechanism of cell death induced by the novel enzyme-prodrug combination, nitroreductase/CB1954, and identification of synergism with 5-fluorouracil
por: Palmer, D H, et al.
Publicado: (2003)

Pre-treatment assay of 5-fluorouracil degradation rate (5-FUDR) to improve prediction of 5-fluorouracil toxicity in gastro-esophageal cancer
por: Borro, Marina, et al.
Publicado: (2016)

Alteration of ribosome function upon 5-fluorouracil treatment favors cancer cell drug-tolerance
por: Therizols, Gabriel, et al.
Publicado: (2022)

Continuous 5-fluorouracil in the treatment of breast cancer.
por: Cameron, D. A., et al.
Publicado: (1994)

Cannot write session to /tmp/vufind_sessions/sess_st6hljpe8ahrp64cpntha4hcsn