Schedule‐dependent Synergism and Antagonism between Raltitrexed (“Tomudex”) and Methotrexate in Human Colon Cancer Cell Lines in vitro

The folate‐dependent enzymes are attractive targets for cancer chemotherapy. Methotrexate (MTX), which inhibits dihydrofolate reductase, has been widely used for the treatment of solid tumors and hematological cancers. Raltitrexed (“Tomudex”), which inhibits thymidylate synthase, is a novel anticanc...

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Detalles Bibliográficos
Autores principales: Kano, Yasuhiko, Akutsu, Miyuki, Tsunoda, Saburo, Suzuki, Kenichi, Yazawa, Yasuo, Furukawa, Yusuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2001
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926578/
https://www.ncbi.nlm.nih.gov/pubmed/11173547
http://dx.doi.org/10.1111/j.1349-7006.2001.tb01050.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926578/
https://www.ncbi.nlm.nih.gov/pubmed/11173547
http://dx.doi.org/10.1111/j.1349-7006.2001.tb01050.x

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