Cargando…

High Expression of Thymidylate Synthase Leads to Resistance to 5‐Fluorouracil in Biliary Tract Carcinoma in vitro

To evaluate the effect of chemotherapy of 5‐fluorouracil (5‐FU) in human biliary tract carcinoma, we studied 5‐FU sensitivity, thymidylate synthase (TS) content, and dihydropyrimidine dehydroge‐nase (DPD) activity in 4 human biliary tract carcinoma cell lines compared to 12 various digestive carcino...

Descripción completa

Detalles Bibliográficos
Autores principales:	Habara, Kazuto, Ajiki, Tetsuo, Kamigaki, Takashi, Nakamura, Takeshi, Kuroda, Yoshikazu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2001
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926613/ https://www.ncbi.nlm.nih.gov/pubmed/11676864 http://dx.doi.org/10.1111/j.1349-7006.2001.tb01068.x

Ejemplares similares

Thymidylate synthase polymorphism and survival of colorectal cancer patients treated with 5-fluorouracil
por: Ulrich, C M, et al.
Publicado: (2002)

Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphisms: relationships with 5-fluorouracil sensitivity
por: Etienne, M-C, et al.
Publicado: (2004)

Thymidylate synthase expression and activity: relation to S-phase parameters and 5-fluorouracil sensitivity.
por: Mirjolet, J. F., et al.
Publicado: (1998)

Trapping of 5-Fluorodeoxyuridine Monophosphate by Thymidylate Synthase Confers Resistance to 5-Fluorouracil
por: Kurasaka, Chinatsu, et al.
Publicado: (2022)

Enhancement of 5-fluorouracil-induced cytotoxicity by leucovorin in 5-fluorouracil-resistant gastric cancer cells with upregulated expression of thymidylate synthase
por: Nakamura, Ayako, et al.
Publicado: (2013)

Reply: Thymidylate synthase polymorphism and survival of colorectal cancer patients treated with 5-fluorouracil
por: Iacopetta, B, et al.
Publicado: (2002)

5-Fluorouracil targets thymidylate synthase in the selective suppression of T(H)17 cell differentiation
por: Wang, Juan, et al.
Publicado: (2016)

Trifluridine/tipiracil overcomes the resistance of human gastric 5-fluorouracil-refractory cells with high thymidylate synthase expression
por: Matsuoka, Kazuaki, et al.
Publicado: (2018)

Multi-level gene expression profiles affected by thymidylate synthase and 5-fluorouracil in colon cancer
por: Xi, Yaguang, et al.
Publicado: (2006)

Dynamic Modulation of Thymidylate Synthase Gene Expression and Fluorouracil Sensitivity in Human Colorectal Cancer Cells
por: Wakasa, Kentaro, et al.
Publicado: (2015)

Effect of Hammerhead Ribozyme against Human Thymidylate Synthase on the Cytotoxicity of Thymidylate Synthase Inhibitors
por: Kobayashi, Hiroyuki, et al.
Publicado: (1995)

MicroRNA-433 negatively regulates the expression of thymidylate synthase (TYMS) responsible for 5-fluorouracil sensitivity in HeLa cells
por: Gotanda, Keisuke, et al.
Publicado: (2013)

Prolonged and enhanced suppression of thymidylate synthase by weekly 24-h infusion of high-dose 5-fluorouracil
por: Yeh, K-H, et al.
Publicado: (2000)

CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil
por: Almqvist, Helena, et al.
Publicado: (2016)

Pancytopenia and Severe Gastrointestinal Toxicities Associated with 5-Fluorouracil in a Patient with Thymidylate Synthase (TYMS) Polymorphism
por: Wang, Bo, et al.
Publicado: (2016)

Apigenin enhances apoptosis induction by 5-fluorouracil through regulation of thymidylate synthase in colorectal cancer cells
por: Yang, Changwon, et al.
Publicado: (2021)

Trichinella pseudospiralis vs. T. spiralis thymidylate synthase gene structure and T. pseudospiralis thymidylate synthase retrogene sequence
por: Jagielska, Elżbieta, et al.
Publicado: (2014)

Study of Thymidylate Synthase (TS) and Dihydropyrimidine Dehydrogenase (DPD) Expressions on 5-Fluorouracil in Oral Squamous Cell Carcinoma
por: Akhter, Khaleda, et al.
Publicado: (2019)

MicroRNA‐375‐3p enhances chemosensitivity to 5‐fluorouracil by targeting thymidylate synthase in colorectal cancer
por: Xu, Fei, et al.
Publicado: (2020)

Regulation of 5‐fluorodeoxyuridine monophosphate‐thymidylate synthase ternary complex levels by autophagy confers resistance to 5‐fluorouracil
por: Nishizawa, Nana, et al.
Publicado: (2022)

Conservation and Role of Electrostatics in Thymidylate Synthase
por: Garg, Divita, et al.
Publicado: (2015)

A polymorphism in the enhancer region of the thymidylate synthase promoter influences the survival of colorectal cancer patients treated with 5-fluorouracil
por: Iacopetta, B, et al.
Publicado: (2001)

Liver-only metastatic colorectal cancer patients and thymidylate synthase polymorphisms for predicting response to 5-fluorouracil-based chemotherapy
por: Graziano, F, et al.
Publicado: (2008)

The effect of dose and interval between 5-fluorouracil and leucovorin on the formation of thymidylate synthase ternary complex in human cancer cells.
por: Drake, J. C., et al.
Publicado: (1995)

Analysis of the Thymidylate Synthase Gene Structure in Colorectal Cancer Patients and Its Possible Relation with the 5-Fluorouracil Drug Response
por: Calascibetta, A., et al.
Publicado: (2010)

Transcriptional Activation and Cell Cycle Block Are the Keys for 5-Fluorouracil Induced Up-Regulation of Human Thymidylate Synthase Expression
por: Ligabue, Alessio, et al.
Publicado: (2012)

Acquired resistance to 5-fluorouracil via HSP90/Src-mediated increase in thymidylate synthase expression in colon cancer
por: Ahn, Ji-Young, et al.
Publicado: (2015)

Uridine triacetate for severe 5-fluorouracil toxicity in a patient with thymidylate synthase gene variation: Potential pharmacogenomic implications
por: Baldeo, Candice, et al.
Publicado: (2018)

Evaluating serum level of thymidylate synthase in post burn keloid patients before and after intralesional injection of 5-fluorouracil
por: Ezzat Mohamad, Noha, et al.
Publicado: (2022)

Substrate Activation in Flavin-Dependent Thymidylate Synthase
por: Mishanina, Tatiana V., et al.
Publicado: (2014)

Concerted versus Stepwise Mechanism in Thymidylate Synthase
por: Islam, Zahidul, et al.
Publicado: (2014)

Expression of thymidylate synthase in gastric cancer patients treated with 5-fluorouracil and doxorubicin-based adjuvant chemotherapy after curative resection
por: Choi, J-H, et al.
Publicado: (2001)

MicroRNA-330 inhibited cell proliferation and enhanced chemosensitivity to 5-fluorouracil in colorectal cancer by directly targeting thymidylate synthase
por: Xu, Weidong, et al.
Publicado: (2017)

Thymidylate synthase expression in circulating tumor cells: A new tool to predict 5‐fluorouracil resistance in metastatic colorectal cancer patients
por: Abdallah, Emne Ali, et al.
Publicado: (2015)

Relationship between the Expression of the Thymidylate Synthase and the Prognosis of Gastric Cancer Patients Treated with Combinational Chemotherapy Regimen Including Fluorouracil, Docetaxel and Cisplatin
por: Aznab, Mozaffar, et al.
Publicado: (2020)

Coptidis Rhizoma Extract Reverses 5-Fluorouracil Resistance in HCT116 Human Colorectal Cancer Cells via Modulation of Thymidylate Synthase
por: Kang, Yong-Hwi, et al.
Publicado: (2021)

Expression of thymidylate synthase and orotate phosphoribosyltransferase in thymic carcinoma
por: YOKOTA, KEISUKE, et al.
Publicado: (2012)

Analysis of mRNA recognition by human thymidylate synthase
por: Brunn, Nicholas D., et al.
Publicado: (2014)

Bacterial versus human thymidylate synthase: Kinetics and functionality
por: Islam, Zahidul, et al.
Publicado: (2018)

Dynamic allostery in substrate binding by human thymidylate synthase
por: Bonin, Jeffrey P, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_vimuhnemfm5hqnhu0cb9rpbnct