Hydroxyurea Induces Site‐specific DNA Damage via Formation of Hydrogen Peroxide and Nitric Oxide

Hydroxyurea is a chemotherapeutic agent used for the treatment of myeloproliferative disorders (MPD) and solid tumors. The mutagenic and carcinogenic potential of hydroxyurea has not been established, although hydroxyurea has been associated with an increased risk of leukemia in MPD patients. To cla...

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Detalles Bibliográficos
Autores principales: Sakano, Katsuhisa, Oikawa, Shinji, Hasegawa, Keishi, Kawanishi, Shosuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2001
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926660/
https://www.ncbi.nlm.nih.gov/pubmed/11714440
http://dx.doi.org/10.1111/j.1349-7006.2001.tb02136.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926660/
https://www.ncbi.nlm.nih.gov/pubmed/11714440
http://dx.doi.org/10.1111/j.1349-7006.2001.tb02136.x

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