A Radicicol Derivative, KF58333, Inhibits Expression of Hypoxia‐inducible Factor‐1α and Vascular Endothelial Growth Factor, Angiogenesis and Growth of Human Breast Cancer Xenografts

A novel oxime derivative of radicicol, KF58333, binds to the heat shock protein 90 (Hsp90) and destabilizes its associated signaling molecules. These effects play a critical role in the growth inhibition of tumor cells. To further investigate the effects of this agent, it was administered to two hum...

Descripción completa

Detalles Bibliográficos
Autores principales: Kurebayashi, Junichi, Otsuki, Takemi, Kurosumi, Masafumi, Soga, Shiro, Akinaga, Shiro, Sonoo, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2001
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926684/
https://www.ncbi.nlm.nih.gov/pubmed/11749701
http://dx.doi.org/10.1111/j.1349-7006.2001.tb02159.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926684/
https://www.ncbi.nlm.nih.gov/pubmed/11749701
http://dx.doi.org/10.1111/j.1349-7006.2001.tb02159.x

Ejemplares similares