Cisplatin‐incorporated Polymeric Micelles Eliminate Nephrotoxicity, While Maintaining Antitumor Activity

cis‐Diamminedichloroplatinum (II) (cisplatin, CDDP), a potent anticancer agent, was bound to the aspartic acid residues of poly(ethylene glycol)‐poly(aspartic acid) (PEG‐P(ASP)) block copolymer by ligand substitution reaction at the platinum atom of CDDP. The polymeric drug thus obtained was observe...

Descripción completa

Detalles Bibliográficos
Autores principales: Mizumura, Yasuo, Matsumura, Yasuhiro, Hamaguchi, Tetsuya, Nishiyama, Nobuhiro, Kataoka, Kazunori, Kawaguchi, Takanori, Hrushesky, William J. M., Moriyasu, Fuminori, Kakizoe, Tadao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2001
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926709/
https://www.ncbi.nlm.nih.gov/pubmed/11267944
http://dx.doi.org/10.1111/j.1349-7006.2001.tb01099.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926709/
https://www.ncbi.nlm.nih.gov/pubmed/11267944
http://dx.doi.org/10.1111/j.1349-7006.2001.tb01099.x

Ejemplares similares