Germline Mutation of Dihydropyrimidine Dehydrogenese Gene among a Japanese Population in Relation to Toxicity to 5‐Fluorouracil

5‐Fluorouracil (5FU) is most commonly used in chemotherapy for human malignancy. Over 80% of administered 5FU is metabolically degraded by dihydropyrimidine dehydrogenase (DPD), a primary and rate‐limiting enzyme in the 5FU metabolic pathway. A DPD‐deficient phenotype among cancer patients, which ha...

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Detalles Bibliográficos
Autores principales: Yamaguchi, Kensei, Aral, Yoshiko, Kanda, Yuzo, Akagi, Kiwamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2001
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926718/
https://www.ncbi.nlm.nih.gov/pubmed/11267945
http://dx.doi.org/10.1111/j.1349-7006.2001.tb01100.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926718/
https://www.ncbi.nlm.nih.gov/pubmed/11267945
http://dx.doi.org/10.1111/j.1349-7006.2001.tb01100.x

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