UCN‐01 (7‐Hydoxystaurosporine) Inhibits in vivo Growth of Human Cancer Cells through Selective Perturbation of G1 Phase Checkpoint Machinery

Mechanisms underlying tumor sensitivity to the antitumor agent UCN‐01 (7‐hydroxystaurosporine) were examined in the nude mouse model using three human tumor xenografts, two pancreatic cancers (PAN‐3‐JCK and CRL 1420) and a breast cancer (MX‐1). UCN‐01 antitumor activity was evaluated in terms of rel...

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Detalles Bibliográficos
Autores principales: Abe, Sadanori, Kubota, Tetsuro, Otani, Yoshihide, Furukawa, Toshiharu, Watanabe, Masahiko, Kumai, Koichiro, Akiyama, Tadakazu, Akinaga, Shiro, Kitajima, Masaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2001
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926745/
https://www.ncbi.nlm.nih.gov/pubmed/11376563
http://dx.doi.org/10.1111/j.1349-7006.2001.tb01127.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926745/
https://www.ncbi.nlm.nih.gov/pubmed/11376563
http://dx.doi.org/10.1111/j.1349-7006.2001.tb01127.x

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