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Mammary Carcinomas Induced in Human c‐Ha‐ras Proto‐oncogene Transgenic Rats Are Estrogen‐independent, but Responsive to d‐Limonene Treatment

We have previously shown that transgenic rats carrying three copies of the human c‐Ha‐ras proto‐ oncogene (Hras128) are highly susceptible to N‐methyl‐N‐nitrosourea (MNU) mammary carcino‐ genesis. All transgenic rats treated with 50 mg/kgMNU, i.v. at 50 days of age, were found to rapidly develop mul...

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Detalles Bibliográficos
Autores principales: Asamoto, Makoto, Ota, Tomonori, Toriyama‐Baba, Hiroyasu, Hokaiwado, Naomi, Naito, Akihiro, Tsuda, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2002
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926874/
https://www.ncbi.nlm.nih.gov/pubmed/11802805
http://dx.doi.org/10.1111/j.1349-7006.2002.tb01197.x