Functional Polymorphism of the Thymidylate Synthase Gene in Colorectal Cancer Accompanied by Frequent Loss of Heterozygosity

The thymidylate synthase (TS) gene has a polymorphic repeated sequence in its 5′‐untranslated region. The repeat length is associated with TS protein expression, which suggests that we may be able to predict the efficacy of 5‐fluorouracil (S‐FU)‐based chemotherapy from a patient's TS genotype d...

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Detalles Bibliográficos
Autores principales: Kawakami, Kazuyuki, Ishida, Yoshinori, Danenberg, Kathleen D., Omura, Kenji, Watanabe, Go, Danenberg, Peter V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2002
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926893/
https://www.ncbi.nlm.nih.gov/pubmed/12460463
http://dx.doi.org/10.1111/j.1349-7006.2002.tb01227.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926893/
https://www.ncbi.nlm.nih.gov/pubmed/12460463
http://dx.doi.org/10.1111/j.1349-7006.2002.tb01227.x

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