Enzymatically oxidized phospholipids restore thrombin generation in coagulation factor deficiencies

Hemostatic defects are treated using coagulation factors; however, clot formation also requires a procoagulant phospholipid (PL) surface. Here, we show that innate immune cell–derived enzymatically oxidized phospholipids (eoxPL) termed hydroxyeicosatetraenoic acid–phospholipids (HETE-PLs) restore he...

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Detalles Bibliográficos
Autores principales: Slatter, David A., Percy, Charles L., Allen-Redpath, Keith, Gajsiewicz, Joshua M., Brooks, Nick J., Clayton, Aled, Tyrrell, Victoria J., Rosas, Marcela, Lauder, Sarah N., Watson, Andrew, Dul, Maria, Garcia-Diaz, Yoel, Aldrovandi, Maceler, Heurich, Meike, Hall, Judith, Morrissey, James H., Lacroix-Desmazes, Sebastien, Delignat, Sandrine, Jenkins, P. Vincent, Collins, Peter W., O’Donnell, Valerie B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926910/
https://www.ncbi.nlm.nih.gov/pubmed/29563336
http://dx.doi.org/10.1172/jci.insight.98459

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926910/
https://www.ncbi.nlm.nih.gov/pubmed/29563336
http://dx.doi.org/10.1172/jci.insight.98459

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