Differential Mechanisms of Constitutive Akt/PKB Activation and Its Influence on Gene Expression in Pancreatic Cancer Cells

Activated Akt/protein kinase B transmits oncogenic signals leading to inhibition of apoptosis, cellular proliferation, and tolerance to hypoxia. Presently, mutational inactivation of PTEN and activation of Ras are considered to be the major causes of Akt activation. Here we report differential mecha...

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Detalles Bibliográficos
Autores principales: Matsumoto, Joe, Kaneda, Masako, Tada, Mitsuhiro, Hamada, Jun‐ichi, Okushiba, Shunichi, Kondo, Satoshi, Katoh, Hiroyuki, Moriuchi, Tetsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2002
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926936/
https://www.ncbi.nlm.nih.gov/pubmed/12495471
http://dx.doi.org/10.1111/j.1349-7006.2002.tb01240.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926936/
https://www.ncbi.nlm.nih.gov/pubmed/12495471
http://dx.doi.org/10.1111/j.1349-7006.2002.tb01240.x

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