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Hammerhead Ribozyme against γ‐Glutamylcysteine Synthetase Attenuates Resistance to Ionizing Radiation and Cisplatin in Human T98G Glioblastoma Cells
Glioblastoma cells are highly malignant and show resistance to ionizing radiation, as well as anti‐cancer drugs. This resistance to cancer therapy is often associated with a high concentration of glutathione (GSH). In this study, the effect of continuous down‐regulation of γ‐glutamylcysteine synthet...
Autores principales: | Tani, Masaharu, Goto, Shinji, Kamada, Kensaku, Mori, Katsuharu, Urata, Yoshishige, Ihara, Yoshito, Kijima, Hiroshi, Ueyama, Yoshito, Shibata, Shobu, Kondo, Takahito |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2002
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927042/ https://www.ncbi.nlm.nih.gov/pubmed/12079521 http://dx.doi.org/10.1111/j.1349-7006.2002.tb01311.x |
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