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Dose of Adenoviral Vectors Expressing Interleukin‐2 Plays an Important Role in Combined Gene Therapy with Cytosine Deaminase/5–Fluorocytosine: Preclinical Consideration

Using a syngeneic murine model, we investigated the therapeutic efficacy of combined gene therapy using adenoviral vectors expressing murine interleukin‐2 (AdmIL‐2) and Escherichia coli cytosine deaminase (AdCD). In a subcutaneous tumor model, tumor‐bearing mice were treated with an intratumoral inj...

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Detalles Bibliográficos
Autores principales:	Nakamori, Mikihito, Iwahashi, Makoto, Ueda, Kentaro, Tsunoda, Takuya, Terasawa, Hiroshi, Hamada, Hirofumi, Yamaue, Hiroki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2002
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927048/ https://www.ncbi.nlm.nih.gov/pubmed/12079520 http://dx.doi.org/10.1111/j.1349-7006.2002.tb01310.x

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