A novel mechanism of RNase L inhibition: Theiler's virus L* protein prevents 2-5A from binding to RNase L

The OAS/RNase L pathway is one of the best-characterized effector pathways of the IFN antiviral response. It inhibits the replication of many viruses and ultimately promotes apoptosis of infected cells, contributing to the control of virus spread. However, viruses have evolved a range of escape stra...

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Detalles Bibliográficos
Autores principales: Drappier, Melissa, Jha, Babal Kant, Stone, Sasha, Elliott, Ruth, Zhang, Rong, Vertommen, Didier, Weiss, Susan R., Silverman, Robert H., Michiels, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927464/
https://www.ncbi.nlm.nih.gov/pubmed/29652922
http://dx.doi.org/10.1371/journal.ppat.1006989

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927464/
https://www.ncbi.nlm.nih.gov/pubmed/29652922
http://dx.doi.org/10.1371/journal.ppat.1006989

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