All-atom molecular dynamics of the HBV capsid reveals insights into biological function and cryo-EM resolution limits

The hepatitis B virus capsid represents a promising therapeutic target. Experiments suggest the capsid must be flexible to function; however, capsid structure and dynamics have not been thoroughly characterized in the absence of icosahedral symmetry constraints. Here, all-atom molecular dynamics sim...

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Detalles Bibliográficos
Autores principales: Hadden, Jodi A, Perilla, Juan R, Schlicksup, Christopher John, Venkatakrishnan, Balasubramanian, Zlotnick, Adam, Schulten, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927769/
https://www.ncbi.nlm.nih.gov/pubmed/29708495
http://dx.doi.org/10.7554/eLife.32478

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927769/
https://www.ncbi.nlm.nih.gov/pubmed/29708495
http://dx.doi.org/10.7554/eLife.32478

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