Deep sequencing and flow cytometric characterization of expanded effector memory CD8(+)CD57(+) T cells frequently reveals T-cell receptor Vβ oligoclonality and CDR3 homology in acquired aplastic anemia

Oligoclonal expansion of CD8(+) CD28(−) lymphocytes has been considered indirect evidence for a pathogenic immune response in acquired aplastic anemia. A subset of CD8(+) CD28(−) cells with CD57 expression, termed effector memory cells, is expanded in several immune-mediated diseases and may have a...

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Detalles Bibliográficos
Autores principales: Giudice, Valentina, Feng, Xingmin, Lin, Zenghua, Hu, Wei, Zhang, Fanmao, Qiao, Wangmin, Ibanez, Maria del Pilar Fernandez, Rios, Olga, Young, Neal S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927970/
https://www.ncbi.nlm.nih.gov/pubmed/29419434
http://dx.doi.org/10.3324/haematol.2017.176701

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927970/
https://www.ncbi.nlm.nih.gov/pubmed/29419434
http://dx.doi.org/10.3324/haematol.2017.176701

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