MSH6 haploinsufficiency at relapse contributes to the development of thiopurine resistance in pediatric B-lymphoblastic leukemia

Survival of children with relapsed acute lymphoblastic leukemia is poor, and understanding mechanisms underlying resistance is essential to developing new therapy. Relapse-specific heterozygous deletions in MSH6, a crucial part of DNA mismatch repair, are frequently detected. Our aim was to determin...

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Detalles Bibliográficos
Autores principales: Evensen, Nikki A., Madhusoodhan, P. Pallavi, Meyer, Julia, Saliba, Jason, Chowdhury, Ashfiyah, Araten, David J., Nersting, Jacob, Bhatla, Teena, Vincent, Tiffaney L., Teachey, David, Hunger, Stephen P., Yang, Jun, Schmiegelow, Kjeld, Carroll, William L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927991/
https://www.ncbi.nlm.nih.gov/pubmed/29449434
http://dx.doi.org/10.3324/haematol.2017.176362

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927991/
https://www.ncbi.nlm.nih.gov/pubmed/29449434
http://dx.doi.org/10.3324/haematol.2017.176362

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