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Pathway-based dissection of the genomic heterogeneity of cancer hallmarks’ acquisition with SLAPenrich
Cancer hallmarks are evolutionary traits required by a tumour to develop. While extensively characterised, the way these traits are achieved through the accumulation of somatic mutations in key biological pathways is not fully understood. To shed light on this subject, we characterised the landscape...
Autores principales: | Iorio, Francesco, Garcia-Alonso, Luz, Brammeld, Jonathan S., Martincorena, Iňigo, Wille, David R., McDermott, Ultan, Saez-Rodriguez, Julio |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928049/ https://www.ncbi.nlm.nih.gov/pubmed/29713020 http://dx.doi.org/10.1038/s41598-018-25076-6 |
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