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G-395A polymorphism in the promoter region of the KLOTHO gene associates with frailty among the oldest-old

Frailty is characterized by a decline in physiological reserve and increased vulnerability. Previous studies have shown that KLOTHO (KL) plays a protective role in several age-related diseases. We hypothesize a probable protective effect of KL on frailty in the elderly population and included a coho...

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Autores principales: Hao, Qiukui, Wang, Yuting, Ding, Xiang, Dong, Biao, Yang, Ming, Dong, Birong, Wei, Yuquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928057/
https://www.ncbi.nlm.nih.gov/pubmed/29712948
http://dx.doi.org/10.1038/s41598-018-25040-4
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author Hao, Qiukui
Wang, Yuting
Ding, Xiang
Dong, Biao
Yang, Ming
Dong, Birong
Wei, Yuquan
author_facet Hao, Qiukui
Wang, Yuting
Ding, Xiang
Dong, Biao
Yang, Ming
Dong, Birong
Wei, Yuquan
author_sort Hao, Qiukui
collection PubMed
description Frailty is characterized by a decline in physiological reserve and increased vulnerability. Previous studies have shown that KLOTHO (KL) plays a protective role in several age-related diseases. We hypothesize a probable protective effect of KL on frailty in the elderly population and included a cohort of Chinese nonagenarians and centenarians for our study. This study is part of a cross-sectional study and secondary analysis of the Project of Longevity and Aging in Dujiangyan (PLAD) study, which was conducted in Southwest China. Community-dwelling Chinese residents aged 90 years or older were included in this study. Frailty was determined using the FRAIL scale as proposed by the International Association of Nutrition and Aging. On the FRAIL scale, frailty was defined by a score of ≥3. G-395A (rs1207568) genotyping of the promoter region of the KL gene was performed using TaqMan allelic discrimination assay. A total of 632 participants (68.4% females; mean age: 93.5 ± 3.2 years) were included. KL G-395A polymorphism genotype frequencies were 1.7% AA, 25.6% GA, and 72.7% GG in our sample. GG genotype frequencies for the frailty and control groups were 83.6% and 71.2%, respectively. Frailty prevalence was significantly lower in the GA+AA group when compared to the GG genotype group (6.9% vs. 13.3%, P = 0.026). In addition, subjects with a GA+AA genotype had a significantly lower risk of frailty (odds ratio (OR): 0.47, 95% confidence interval (CI) 0.23 to 0.97, P = 0.040) compared to the GG genotype after adjusting for age, gender, education level, smoking, alcohol consumption, exercise, body mass index (BMI), cognitive impairment, and other potential factors. KL-395A allele carrying genotypes (GA and AA) is associated with a lower risk of frailty relative to GG genotypes in a sample of Chinese nonagenarians and centenarians.
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spelling pubmed-59280572018-05-07 G-395A polymorphism in the promoter region of the KLOTHO gene associates with frailty among the oldest-old Hao, Qiukui Wang, Yuting Ding, Xiang Dong, Biao Yang, Ming Dong, Birong Wei, Yuquan Sci Rep Article Frailty is characterized by a decline in physiological reserve and increased vulnerability. Previous studies have shown that KLOTHO (KL) plays a protective role in several age-related diseases. We hypothesize a probable protective effect of KL on frailty in the elderly population and included a cohort of Chinese nonagenarians and centenarians for our study. This study is part of a cross-sectional study and secondary analysis of the Project of Longevity and Aging in Dujiangyan (PLAD) study, which was conducted in Southwest China. Community-dwelling Chinese residents aged 90 years or older were included in this study. Frailty was determined using the FRAIL scale as proposed by the International Association of Nutrition and Aging. On the FRAIL scale, frailty was defined by a score of ≥3. G-395A (rs1207568) genotyping of the promoter region of the KL gene was performed using TaqMan allelic discrimination assay. A total of 632 participants (68.4% females; mean age: 93.5 ± 3.2 years) were included. KL G-395A polymorphism genotype frequencies were 1.7% AA, 25.6% GA, and 72.7% GG in our sample. GG genotype frequencies for the frailty and control groups were 83.6% and 71.2%, respectively. Frailty prevalence was significantly lower in the GA+AA group when compared to the GG genotype group (6.9% vs. 13.3%, P = 0.026). In addition, subjects with a GA+AA genotype had a significantly lower risk of frailty (odds ratio (OR): 0.47, 95% confidence interval (CI) 0.23 to 0.97, P = 0.040) compared to the GG genotype after adjusting for age, gender, education level, smoking, alcohol consumption, exercise, body mass index (BMI), cognitive impairment, and other potential factors. KL-395A allele carrying genotypes (GA and AA) is associated with a lower risk of frailty relative to GG genotypes in a sample of Chinese nonagenarians and centenarians. Nature Publishing Group UK 2018-04-30 /pmc/articles/PMC5928057/ /pubmed/29712948 http://dx.doi.org/10.1038/s41598-018-25040-4 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Hao, Qiukui
Wang, Yuting
Ding, Xiang
Dong, Biao
Yang, Ming
Dong, Birong
Wei, Yuquan
G-395A polymorphism in the promoter region of the KLOTHO gene associates with frailty among the oldest-old
title G-395A polymorphism in the promoter region of the KLOTHO gene associates with frailty among the oldest-old
title_full G-395A polymorphism in the promoter region of the KLOTHO gene associates with frailty among the oldest-old
title_fullStr G-395A polymorphism in the promoter region of the KLOTHO gene associates with frailty among the oldest-old
title_full_unstemmed G-395A polymorphism in the promoter region of the KLOTHO gene associates with frailty among the oldest-old
title_short G-395A polymorphism in the promoter region of the KLOTHO gene associates with frailty among the oldest-old
title_sort g-395a polymorphism in the promoter region of the klotho gene associates with frailty among the oldest-old
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928057/
https://www.ncbi.nlm.nih.gov/pubmed/29712948
http://dx.doi.org/10.1038/s41598-018-25040-4
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