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G-395A polymorphism in the promoter region of the KLOTHO gene associates with frailty among the oldest-old
Frailty is characterized by a decline in physiological reserve and increased vulnerability. Previous studies have shown that KLOTHO (KL) plays a protective role in several age-related diseases. We hypothesize a probable protective effect of KL on frailty in the elderly population and included a coho...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928057/ https://www.ncbi.nlm.nih.gov/pubmed/29712948 http://dx.doi.org/10.1038/s41598-018-25040-4 |