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Sauchinone controls hepatic cholesterol homeostasis by the negative regulation of PCSK9 transcriptional network
Whole-transcriptome analysis and western blotting of sauchinone-treated HepG2 cells demonstrated that sauchinone regulated genes relevant to cholesterol metabolism and synthesis. In particular, it was found that the expression of proprotein convertase subtilisin/kexin type 9 (PCSK9) was downregulate...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928089/ https://www.ncbi.nlm.nih.gov/pubmed/29712938 http://dx.doi.org/10.1038/s41598-018-24935-6 |