Native mass spectrometry combined with enzymatic dissection unravels glycoform heterogeneity of biopharmaceuticals

Robust manufacturing processes resulting in consistent glycosylation are critical for the efficacy and safety of biopharmaceuticals. Information on glycosylation can be obtained by conventional bottom–up methods but is often limited to the glycan or glycopeptide level. Here, we apply high-resolution...

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Detalles Bibliográficos
Autores principales: Wohlschlager, Therese, Scheffler, Kai, Forstenlehner, Ines C., Skala, Wolfgang, Senn, Stefan, Damoc, Eugen, Holzmann, Johann, Huber, Christian G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928108/
https://www.ncbi.nlm.nih.gov/pubmed/29712889
http://dx.doi.org/10.1038/s41467-018-04061-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928108/
https://www.ncbi.nlm.nih.gov/pubmed/29712889
http://dx.doi.org/10.1038/s41467-018-04061-7

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