Linear mitochondrial DNA is rapidly degraded by components of the replication machinery

Emerging gene therapy approaches that aim to eliminate pathogenic mutations of mitochondrial DNA (mtDNA) rely on efficient degradation of linearized mtDNA, but the enzymatic machinery performing this task is presently unknown. Here, we show that, in cellular models of restriction endonuclease-induce...

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Detalles Bibliográficos
Autores principales: Peeva, Viktoriya, Blei, Daniel, Trombly, Genevieve, Corsi, Sarah, Szukszto, Maciej J., Rebelo-Guiomar, Pedro, Gammage, Payam A., Kudin, Alexei P., Becker, Christian, Altmüller, Janine, Minczuk, Michal, Zsurka, Gábor, Kunz, Wolfram S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928156/
https://www.ncbi.nlm.nih.gov/pubmed/29712893
http://dx.doi.org/10.1038/s41467-018-04131-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928156/
https://www.ncbi.nlm.nih.gov/pubmed/29712893
http://dx.doi.org/10.1038/s41467-018-04131-w

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