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Muscarinic M4 Receptors on Cholinergic and Dopamine D1 Receptor-Expressing Neurons Have Opposing Functionality for Positive Reinforcement and Influence Impulsivity

The neurotransmitter acetylcholine has been implicated in reward learning and drug addiction. However, the roles of the various cholinergic receptor subtypes on different neuron populations remain elusive. Here we study the function of muscarinic M4 receptors (M4Rs) in dopamine D1 receptor (D1R) exp...

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Detalles Bibliográficos
Autores principales: Klawonn, Anna M., Wilhelms, Daniel B., Lindström, Sarah H., Singh, Anand Kumar, Jaarola, Maarit, Wess, Jürgen, Fritz, Michael, Engblom, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928231/
https://www.ncbi.nlm.nih.gov/pubmed/29740282
http://dx.doi.org/10.3389/fnmol.2018.00139