Physiologically-based pharmacokinetic predictions of intestinal BCRP-mediated drug interactions of rosuvastatin in Koreans

It was recently reported that the C(max) and AUC of rosuvastatin increases when it is coadministered with telmisartan and cyclosporine. Rosuvastatin is known to be a substrate of OATP1B1, OATP1B3, NTCP, and BCRP transporters. The aim of this study was to explore the mechanism of the interactions bet...

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Detalles Bibliográficos
Autores principales: Bae, Soo Hyeon, Park, Wan-Su, Han, Seunghoon, Park, Gab-jin, Lee, Jongtae, Hong, Taegon, Jeon, Sangil, Yim, Dong-Seok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Physiological Society and The Korean Society of Pharmacology 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928345/
https://www.ncbi.nlm.nih.gov/pubmed/29719454
http://dx.doi.org/10.4196/kjpp.2018.22.3.321

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928345/
https://www.ncbi.nlm.nih.gov/pubmed/29719454
http://dx.doi.org/10.4196/kjpp.2018.22.3.321

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