Pyrimidine Nucleosides with a Reactive (β-Chlorovinyl)sulfone or (β-Keto)sulfone Group at the C5 Position, Their Reactions with Nucleophiles and Electrophiles, and Their Polymerase-Catalyzed Incorporation into DNA

[Image: see text] Transition-metal-catalyzed chlorosulfonylation of 5-ethynylpyrimidine nucleosides provided (E)-5-(β-chlorovinyl)sulfones A, which undergo nucleophilic substitution with amines or thiols affording B. The treatment of vinyl sulfones A with ammonia followed by acid-catalyzed hydrolysi...

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Detalles Bibliográficos
Autores principales: Suzol, Sazzad H., Howlader, A. Hasan, Wen, Zhiwei, Ren, Yaou, Laverde, Eduardo E., Garcia, Carol, Liu, Yuan, Wnuk, Stanislaw F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928487/
https://www.ncbi.nlm.nih.gov/pubmed/29732453
http://dx.doi.org/10.1021/acsomega.8b00584

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928487/
https://www.ncbi.nlm.nih.gov/pubmed/29732453
http://dx.doi.org/10.1021/acsomega.8b00584

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