α-Synuclein fibril-induced paradoxical structural and functional defects in hippocampal neurons

Neuronal inclusions composed of α-synuclein (α-syn) characterize Parkinson’s Disease (PD) and Dementia with Lewy bodies (DLB). Cognitive dysfunction defines DLB, and up to 80% of PD patients develop dementia. α-Syn inclusions are abundant in the hippocampus, yet functional consequences are unclear....

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Detalles Bibliográficos
Autores principales: Froula, Jessica M., Henderson, Benjamin W., Gonzalez, Jose Carlos, Vaden, Jada H., Mclean, John W., Wu, Yumei, Banumurthy, Gokulakrishna, Overstreet-Wadiche, Linda, Herskowitz, Jeremy H., Volpicelli-Daley, Laura A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928584/
https://www.ncbi.nlm.nih.gov/pubmed/29716652
http://dx.doi.org/10.1186/s40478-018-0537-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928584/
https://www.ncbi.nlm.nih.gov/pubmed/29716652
http://dx.doi.org/10.1186/s40478-018-0537-x

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