Cargando…

α-Synuclein fibril-induced paradoxical structural and functional defects in hippocampal neurons

Neuronal inclusions composed of α-synuclein (α-syn) characterize Parkinson’s Disease (PD) and Dementia with Lewy bodies (DLB). Cognitive dysfunction defines DLB, and up to 80% of PD patients develop dementia. α-Syn inclusions are abundant in the hippocampus, yet functional consequences are unclear....

Descripción completa

Detalles Bibliográficos
Autores principales:	Froula, Jessica M., Henderson, Benjamin W., Gonzalez, Jose Carlos, Vaden, Jada H., Mclean, John W., Wu, Yumei, Banumurthy, Gokulakrishna, Overstreet-Wadiche, Linda, Herskowitz, Jeremy H., Volpicelli-Daley, Laura A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928584/ https://www.ncbi.nlm.nih.gov/pubmed/29716652 http://dx.doi.org/10.1186/s40478-018-0537-x

Ejemplares similares

The readily-releasable pool dynamically regulates multivesicular release
por: Vaden, Jada H, et al.
Publicado: (2019)

Non-synaptic signaling from cerebellar climbing fibers modulates Golgi cell activity
por: Nietz, Angela K, et al.
Publicado: (2017)

Best Practices for Generating and Using Alpha-Synuclein Pre-Formed Fibrils to Model Parkinson’s Disease in Rodents
por: Polinski, Nicole K., et al.
Publicado: (2018)

Trehalose does not improve neuronal survival on exposure to alpha-synuclein pre-formed fibrils
por: Redmann, Matthew, et al.
Publicado: (2017)

Initiation and propagation of α-synuclein aggregation in the nervous system
por: Hijaz, Baraa A., et al.
Publicado: (2020)

Parvalbumin interneurons provide spillover to newborn and mature dentate granule cells
por: Vaden, Ryan J, et al.
Publicado: (2020)

Multiplicity of α-Synuclein Aggregated Species and Their Possible Roles in Disease
por: Gracia, Pablo, et al.
Publicado: (2020)

Adult-born neurons modify excitatory synaptic transmission to existing neurons
por: Adlaf, Elena W, et al.
Publicado: (2017)

Correction: Adult-born neurons modify excitatory synaptic transmission to existing neurons
por: Adlaf, Elena W, et al.
Publicado: (2022)

Gut-seeded α-synuclein fibrils promote gut dysfunction and brain pathology specifically in aged mice
por: Challis, Collin, et al.
Publicado: (2020)

Behavioral defects associated with amygdala and cortical dysfunction in mice with seeded α-synuclein inclusions
por: Stoyka, Lindsay E., et al.
Publicado: (2019)

Adult Hippocampal Neurogenesis and Plasticity in the Infrapyramidal Bundle of the Mossy Fiber Projection: I. Co-Regulation by Activity
por: Römer, Benedikt, et al.
Publicado: (2011)

Ivy/Neurogliaform Interneurons Coordinate Activity in the Neurogenic Niche
por: Markwardt, Sean J., et al.
Publicado: (2011)

Dynamic functions of GABA signaling during granule cell maturation
por: Dieni, Cristina V., et al.
Publicado: (2013)

The effect of Bacopa monnieri on gene expression levels in SH-SY5Y human neuroblastoma cells
por: Leung, How-Wing, et al.
Publicado: (2017)

Afferent convergence to a shared population of interneuron AMPA receptors
por: Pennock, Reagan L., et al.
Publicado: (2023)

Enhanced Integration of Newborn Neurons after Neonatal Insults
por: Pugh, Phyllis, et al.
Publicado: (2011)

Low excitatory innervation balances high intrinsic excitability of immature dentate neurons
por: Dieni, Cristina V., et al.
Publicado: (2016)

Multifaceted circuit functions of adult-born neurons
por: Dieni, Cristina V., et al.
Publicado: (2019)

Alpha-synuclein in Parkinson’s disease and other synucleinopathies: from overt neurodegeneration back to early synaptic dysfunction
por: Calabresi, Paolo, et al.
Publicado: (2023)

RGS6 Mediates Effects of Voluntary Running on Adult Hippocampal Neurogenesis
por: Gao, Yu, et al.
Publicado: (2020)

The little brain and the seahorse: Cerebellar-hippocampal interactions
por: Froula, Jessica M., et al.
Publicado: (2023)

Functionalization of α-synuclein fibrils
por: Povilonienė, Simona, et al.
Publicado: (2015)

Formation of α-synuclein Lewy neurite–like aggregates in axons impedes the transport of distinct endosomes
por: Volpicelli-Daley, Laura A., et al.
Publicado: (2014)

Differential Expression of Alpha-Synuclein in Hippocampal Neurons
por: Taguchi, Katsutoshi, et al.
Publicado: (2014)

On the Cluster Formation of α-Synuclein Fibrils
por: Dubackic, Marija, et al.
Publicado: (2021)

Lipids and atrial fibrillation: New insights into a paradox
por: Sagris, Dimitrios, et al.
Publicado: (2022)

Templated α-Synuclein Inclusion Formation Is Independent of Endogenous Tau
por: Stoyka, Lindsay E., et al.
Publicado: (2021)

Distinct roles of Bdnf I and Bdnf IV transcript variant expression in hippocampal neurons
por: Bach, Svitlana V., et al.
Publicado: (2023)

α-Synuclein-derived lipoparticles in the study of α-Synuclein amyloid fibril formation
por: Falke, Marcel, et al.
Publicado: (2019)

Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of α-synuclein
por: Brzozowski, Charlotte F., et al.
Publicado: (2021)

α-Synuclein-mediated neurodegeneration in Dementia with Lewy bodies: the pathobiology of a paradox
por: Simon, Christopher, et al.
Publicado: (2021)

Alpha-synuclein alters the faecal viromes of rats in a gut-initiated model of Parkinson’s disease
por: Stockdale, Stephen R., et al.
Publicado: (2021)

Cryo-EM structure of alpha-synuclein fibrils
por: Guerrero-Ferreira, Ricardo, et al.
Publicado: (2018)

Increased Dynamics of α-Synuclein Fibrils by β-Synuclein Leads to Reduced Seeding and Cytotoxicity
por: Yang, Xue, et al.
Publicado: (2019)

Circadian regulation of dentate gyrus excitability mediated by G-protein signaling
por: Carlos Gonzalez, Jose, et al.
Publicado: (2023)

Lipid‐induced polymorphic amyloid fibril formation by α‐synuclein
por: Singh, Bhanu P., et al.
Publicado: (2023)

Dynamic transport and localization of alpha-synuclein in primary hippocampal neurons
por: Yang, Mong-Lin, et al.
Publicado: (2010)

LRRK2 Antisense Oligonucleotides Ameliorate α-Synuclein Inclusion Formation in a Parkinson’s Disease Mouse Model
por: Zhao, Hien Tran, et al.
Publicado: (2017)

LRRK2 Antisense Oligonucleotides Ameliorate α-Synuclein Inclusion Formation in a Parkinson’s Disease Mouse Model
por: Zhao, Hien Tran, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_oofupcjvu773pfe790udko2e2r