DNA damage induced by human CD40 ligand mutant promotes senescence and induces demethylation of GATA4 in lung cancer

The ligand of CD40, known as CD154 or CD40L, is the key to immunostimulatory and anticancer activity, but how CD40L affects cellular senescence is unclear. Thus, we studied a membrane-stable mutant form CD40L (CD40L-M) to explore tumor growth and cellular senescence in CD40-positive NSCLC cells. We...

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Detalles Bibliográficos
Autores principales: Li, Yue, Wei, Yunyan, Yuan, Weiwei, Huang, Qiqing, Zhao, Yaya, Zhao, Weihong, Xu, Wei, Wu, Jianqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928763/
https://www.ncbi.nlm.nih.gov/pubmed/29565449
http://dx.doi.org/10.3892/or.2018.6310

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928763/
https://www.ncbi.nlm.nih.gov/pubmed/29565449
http://dx.doi.org/10.3892/or.2018.6310

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