Adipocyte-Derived Exosomal MiR-27a Induces Insulin Resistance in Skeletal Muscle Through Repression of PPARγ

The mechanism by which adipocyte-derived endocrine factors promote insulin resistance in skeletal muscle are not fully understood. MiR-27a is highly expressed in sera of obese individuals with prediabetes and T2DM, and mainly derived by adipose tissues. Thus, miR-27a secreted into circulation by adi...

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Detalles Bibliográficos
Autores principales: Yu, Yang, Du, Hongwei, Wei, Shengnan, Feng, Linjing, Li, Junnan, Yao, Fan, Zhang, Ming, Hatch, Grant M., Chen, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928879/
https://www.ncbi.nlm.nih.gov/pubmed/29721071
http://dx.doi.org/10.7150/thno.22565

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928879/
https://www.ncbi.nlm.nih.gov/pubmed/29721071
http://dx.doi.org/10.7150/thno.22565

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