Transcriptional Dysregulation of MYC Reveals Common Enhancer-Docking Mechanism

Transcriptional dysregulation of the MYC oncogene is among the most frequent events in aggressive tumor cells, and this is generally accomplished by acquisition of a super-enhancer somewhere within the 2.8 Mb TAD where MYC resides. We find that these diverse cancer-specific super-enhancers, differin...

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Detalles Bibliográficos
Autores principales: Schuijers, Jurian, Manteiga, John Colonnese, Weintraub, Abraham Selby, Day, Daniel Sindt, Zamudio, Alicia Viridiana, Hnisz, Denes, Lee, Tong Ihn, Young, Richard Allen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5929158/
https://www.ncbi.nlm.nih.gov/pubmed/29641996
http://dx.doi.org/10.1016/j.celrep.2018.03.056

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5929158/
https://www.ncbi.nlm.nih.gov/pubmed/29641996
http://dx.doi.org/10.1016/j.celrep.2018.03.056

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