Epoxide hydrolysis as a model system for understanding flux through a branched reaction scheme

The epoxide hydrolase StEH1 catalyzes the hydrolysis of trans-methylstyrene oxide to 1-phenyl­propane-1,2-diol. The (S,S)-epoxide is exclusively transformed into the (1R,2S)-diol, while hydrolysis of the (R,R)-epoxide results in a mixture of product enantiomers. In order to understand the difference...

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Detalles Bibliográficos
Autores principales: Janfalk Carlsson, Åsa, Bauer, Paul, Dobritzsch, Doreen, Kamerlin, Shina C. L., Widersten, Mikael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2018
Materias:
Feature Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5929373/
https://www.ncbi.nlm.nih.gov/pubmed/29755743
http://dx.doi.org/10.1107/S2052252518003573

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5929373/
https://www.ncbi.nlm.nih.gov/pubmed/29755743
http://dx.doi.org/10.1107/S2052252518003573

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