Blockage of the mevalonate pathway overcomes the apoptotic resistance to MEK inhibitors with suppressing the activation of Akt in cancer cells

With increasing clinical demands for MEK inhibitors in cancer treatment, overcoming the resistance to MEK inhibitors is an urgent problem to be solved. Numerous reports have shown that MEK inhibition results in the activation of PI3K-Akt signaling, which may confer apoptotic resistance to MEK inhibi...

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Detalles Bibliográficos
Autores principales: Iizuka-Ohashi, Mahiro, Watanabe, Motoki, Sukeno, Mamiko, Morita, Mie, Hoang, Ngoc Thi Hong, Kuchimaru, Takahiro, Kizaka-Kondoh, Shinae, Sowa, Yoshihiro, Sakaguchi, Koichi, Taguchi, Tetsuya, Sakai, Toshiyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5929411/
https://www.ncbi.nlm.nih.gov/pubmed/29731968
http://dx.doi.org/10.18632/oncotarget.24696

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5929411/
https://www.ncbi.nlm.nih.gov/pubmed/29731968
http://dx.doi.org/10.18632/oncotarget.24696

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