Cisplatin-induced ERK1/2 activity promotes G1 to S phase progression which leads to chemoresistance of ovarian cancer cells

The link between ERK1/2 activity and cisplatin cytotoxicity, in association with the cell cycle, in ovarian cancer cell lines resistant (A2780cis; SK-OV-3) and sensitive (A2780) to cisplatin was determined. We observed that cisplatin, at a low concentration enhanced the activation of ERK1/2 in A2780...

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Detalles Bibliográficos
Autores principales: Kielbik, Michal, Krzyzanowski, Damian, Pawlik, Bartlomiej, Klink, Magdalena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5929431/
https://www.ncbi.nlm.nih.gov/pubmed/29731988
http://dx.doi.org/10.18632/oncotarget.24884

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5929431/
https://www.ncbi.nlm.nih.gov/pubmed/29731988
http://dx.doi.org/10.18632/oncotarget.24884

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