Mice lacking the transcriptional regulator Bhlhe40 have enhanced neuronal excitability and impaired synaptic plasticity in the hippocampus

Bhlhe40 is a transcription factor that is highly expressed in the hippocampus; however, its role in neuronal function is not well understood. Here, we used Bhlhe40 null mice on a congenic C57Bl6/J background (Bhlhe40 KO) to investigate the impact of Bhlhe40 on neuronal excitability and synaptic plas...

Descripción completa

Detalles Bibliográficos
Autores principales: Hamilton, Kelly A., Wang, Yue, Raefsky, Sophia M., Berkowitz, Sean, Spangler, Ryan, Suire, Caitlin N., Camandola, Simonetta, Lipsky, Robert H., Mattson, Mark P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5929507/
https://www.ncbi.nlm.nih.gov/pubmed/29715265
http://dx.doi.org/10.1371/journal.pone.0196223

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5929507/
https://www.ncbi.nlm.nih.gov/pubmed/29715265
http://dx.doi.org/10.1371/journal.pone.0196223

Ejemplares similares