Pentoxifylline, dexamethasone and azithromycin demonstrate distinct age-dependent and synergistic inhibition of TLR- and inflammasome-mediated cytokine production in human newborn and adult blood in vitro

INTRODUCTION: Neonatal inflammation, mediated in part through Toll-like receptor (TLR) and inflammasome signaling, contributes to adverse outcomes including organ injury. Pentoxifylline (PTX), a phosphodiesterase inhibitor which potently suppresses cytokine production in newborn cord blood, is a can...

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Detalles Bibliográficos
Autores principales: Speer, Esther M., Dowling, David J., Xu, Jianjin, Ozog, Lukasz S., Mathew, Jaime A., Chander, Avinash, Yin, Donglei, Levy, Ofer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5929513/
https://www.ncbi.nlm.nih.gov/pubmed/29715306
http://dx.doi.org/10.1371/journal.pone.0196352

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5929513/
https://www.ncbi.nlm.nih.gov/pubmed/29715306
http://dx.doi.org/10.1371/journal.pone.0196352

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