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Deciphering the binding behavior of flavonoids to the cyclin dependent kinase 6/cyclin D complex
Flavonoids, a class of natural compounds with variable phenolic structures, have been found to possess anti-cancer activities by modulating different enzymes and receptors like CDK6. To understand the binding behavior of flavonoids that inhibit the active CDK6, molecular dynamics (MD) simulations we...
Autores principales: | Zhang, Jingxiao, Zhang, Lilei, Xu, Yangcheng, Jiang, Shanshan, Shao, Yueyue |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5929560/ https://www.ncbi.nlm.nih.gov/pubmed/29715320 http://dx.doi.org/10.1371/journal.pone.0196651 |
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