Development and validation of an HPLC–MS/MS method for the determination of arginine-vasopressin receptor blocker conivaptan in human plasma and rat liver microsomes: application to a metabolic stability study

PURPOSE: To develop and validate a bio-analytical HPLC–MS/MS method for the determination of conivaptan (CVA) an arginine-vasopressin receptor blocker in human plasma and in rat liver microsomes (RLMs). METHODS: Analytes were separated on a reversed phase C18 column (50 mm × 2.1 mm, 1.8 μm). The mob...

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Detalles Bibliográficos
Autores principales: Alrabiah, Haitham, Kadi, Adnan A., Attwa, Mohamed W., Mostafa, Gamal A. E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930294/
https://www.ncbi.nlm.nih.gov/pubmed/29717376
http://dx.doi.org/10.1186/s13065-018-0414-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930294/
https://www.ncbi.nlm.nih.gov/pubmed/29717376
http://dx.doi.org/10.1186/s13065-018-0414-5

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