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miR-221 stimulates breast cancer cells and cancer-associated fibroblasts (CAFs) through selective interference with the A20/c-Rel/CTGF signaling

BACKGROUND: MicroRNA (miRNAs) are non-coding small RNA molecules that regulate gene expression by inhibiting the translation of target mRNAs. Among several dysregulated miRNAs in human cancer, the up-regulation of miR-221 has been associated with development of a variety of hematologic and solid mal...

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Detalles Bibliográficos
Autores principales: Santolla, Maria Francesca, Lappano, Rosamaria, Cirillo, Francesca, Rigiracciolo, Damiano Cosimo, Sebastiani, Anna, Abonante, Sergio, Tassone, Pierfrancesco, Tagliaferri, Pierosandro, Di Martino, Maria Teresa, Maggiolini, Marcello, Vivacqua, Adele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930435/
https://www.ncbi.nlm.nih.gov/pubmed/29716623
http://dx.doi.org/10.1186/s13046-018-0767-6