The cytidine deaminase under-representation reporter (CDUR) as a tool to study evolution of sequences under deaminase mutational pressure

BACKGROUND: Activation induced deaminase (AID) and apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3 (APOBEC3) are deaminases that mutate C to U on single-stranded DNA (ssDNA). AID is expressed primarily in germinal center B-cells, where it facilitates affinity maturation and class-...

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Detalles Bibliográficos
Autores principales: Shapiro, Maxwell, Meier, Stephen, MacCarthy, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930495/
https://www.ncbi.nlm.nih.gov/pubmed/29716522
http://dx.doi.org/10.1186/s12859-018-2161-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930495/
https://www.ncbi.nlm.nih.gov/pubmed/29716522
http://dx.doi.org/10.1186/s12859-018-2161-y

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