Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration

BACKGROUND: Converging evidence suggests a role for microglia-mediated neuroinflammation in Parkinson’s disease (PD). Animal models of PD can serve as a platform to investigate the role of neuroinflammation in degeneration in PD. However, due to features of the previously available PD models, interp...

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Detalles Bibliográficos
Autores principales: Duffy, Megan F., Collier, Timothy J., Patterson, Joseph R., Kemp, Christopher J., Luk, Kelvin C., Tansey, Malú G., Paumier, Katrina L., Kanaan, Nicholas M., Fischer, Luke D., Polinski, Nicole K., Barth, Olivia L., Howe, Jacob W., Vaikath, Nishant N., Majbour, Nour K., El-Agnaf, Omar M. A., Sortwell, Caryl E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930695/
https://www.ncbi.nlm.nih.gov/pubmed/29716614
http://dx.doi.org/10.1186/s12974-018-1171-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930695/
https://www.ncbi.nlm.nih.gov/pubmed/29716614
http://dx.doi.org/10.1186/s12974-018-1171-z

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