Generation of a PAX6 knockout glioblastoma cell line with changes in cell cycle distribution and sensitivity to oxidative stress

BACKGROUND: The transcription factor PAX6 is expressed in various cancers. In anaplastic astrocytic glioma, PAX6 expression is inversely related to tumor grade, resulting in low PAX6 expression in Glioblastoma, the highest-grade astrocytic glioma. The aim of the present study was to develop a PAX6 k...

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Detalles Bibliográficos
Autores principales: Hegge, Beate, Sjøttem, Eva, Mikkola, Ingvild
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930953/
https://www.ncbi.nlm.nih.gov/pubmed/29716531
http://dx.doi.org/10.1186/s12885-018-4394-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930953/
https://www.ncbi.nlm.nih.gov/pubmed/29716531
http://dx.doi.org/10.1186/s12885-018-4394-6

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