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New opportunities for kinase drug repurposing and target discovery
Protein kinases are major drug targets for oncology. The large size of the kinome, active site conservation and the influence of activation states on drug binding complicates the analysis of their cellular mode of action. In a recent article in Science, Klaeger et al. analysed cellular targets of 24...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931101/ https://www.ncbi.nlm.nih.gov/pubmed/29545596 http://dx.doi.org/10.1038/s41416-018-0045-6 |