New opportunities for kinase drug repurposing and target discovery

Protein kinases are major drug targets for oncology. The large size of the kinome, active site conservation and the influence of activation states on drug binding complicates the analysis of their cellular mode of action. In a recent article in Science, Klaeger et al. analysed cellular targets of 24...

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Detalles Bibliográficos
Autor principal: Knapp, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Editorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931101/
https://www.ncbi.nlm.nih.gov/pubmed/29545596
http://dx.doi.org/10.1038/s41416-018-0045-6
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author Knapp, Stefan
author_facet Knapp, Stefan
author_sort Knapp, Stefan
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description Protein kinases are major drug targets for oncology. The large size of the kinome, active site conservation and the influence of activation states on drug binding complicates the analysis of their cellular mode of action. In a recent article in Science, Klaeger et al. analysed cellular targets of 243 drug candidates providing a large repository of data for drug repurposing.
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spelling pubmed-59311012019-04-03 New opportunities for kinase drug repurposing and target discovery Knapp, Stefan Br J Cancer Editorial Protein kinases are major drug targets for oncology. The large size of the kinome, active site conservation and the influence of activation states on drug binding complicates the analysis of their cellular mode of action. In a recent article in Science, Klaeger et al. analysed cellular targets of 243 drug candidates providing a large repository of data for drug repurposing. Nature Publishing Group UK 2018-03-16 2018-04-03 /pmc/articles/PMC5931101/ /pubmed/29545596 http://dx.doi.org/10.1038/s41416-018-0045-6 Text en © Cancer Research UK 2018 https://creativecommons.org/licenses/by/4.0/This work is published under the standard license to publish agreement. After 12 months the work will become freely available and the license terms will switch to a Creative Commons Attribution 4.0 International licence (CC BY 4.0).
spellingShingle Editorial
Knapp, Stefan
New opportunities for kinase drug repurposing and target discovery
title New opportunities for kinase drug repurposing and target discovery
title_full New opportunities for kinase drug repurposing and target discovery
title_fullStr New opportunities for kinase drug repurposing and target discovery
title_full_unstemmed New opportunities for kinase drug repurposing and target discovery
title_short New opportunities for kinase drug repurposing and target discovery
title_sort new opportunities for kinase drug repurposing and target discovery
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931101/
https://www.ncbi.nlm.nih.gov/pubmed/29545596
http://dx.doi.org/10.1038/s41416-018-0045-6
work_keys_str_mv AT knappstefan newopportunitiesforkinasedrugrepurposingandtargetdiscovery

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