A Whole Animal Platform to Advance A Clinical Kinase Inhibitor Into New Disease Space

Synthetic tailoring of approved drugs for new indications is often difficult, as the most appropriate targets may not be readily apparent and therefore few roadmaps exist to guide chemistry. Here, we report a multidisciplinary approach for accessing novel target and chemical space starting from an F...

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Detalles Bibliográficos
Autores principales: Sonoshita, Masahiro, Scopton, Alex P., Ung, Peter M-U., Murray, Matthew A., Silber, Lisa, Maldonado, Andres Y., Real, Alexander, Schlessinger, Avner, Cagan, Ross L., Dar, Arvin C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931369/
https://www.ncbi.nlm.nih.gov/pubmed/29355849
http://dx.doi.org/10.1038/nchembio.2556

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931369/
https://www.ncbi.nlm.nih.gov/pubmed/29355849
http://dx.doi.org/10.1038/nchembio.2556

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