Deciphering the molecular determinants of cholinergic anthelmintic sensitivity in nematodes: When novel functional validation approaches highlight major differences between the model Caenorhabditis elegans and parasitic species

Cholinergic agonists such as levamisole and pyrantel are widely used as anthelmintics to treat parasitic nematode infestations. These drugs elicit spastic paralysis by activating acetylcholine receptors (AChRs) expressed in nematode body wall muscles. In the model nematode Caenorhabditis elegans, ge...

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Detalles Bibliográficos
Autores principales: Blanchard, Alexandra, Guégnard, Fabrice, Charvet, Claude L., Crisford, Anna, Courtot, Elise, Sauvé, Christine, Harmache, Abdallah, Duguet, Thomas, O’Connor, Vincent, Castagnone-Sereno, Philippe, Reaves, Barbara, Wolstenholme, Adrian J., Beech, Robin N., Holden-Dye, Lindy, Neveu, Cedric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931475/
https://www.ncbi.nlm.nih.gov/pubmed/29719008
http://dx.doi.org/10.1371/journal.ppat.1006996

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931475/
https://www.ncbi.nlm.nih.gov/pubmed/29719008
http://dx.doi.org/10.1371/journal.ppat.1006996

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